DegronMD

Uniprot ID: Q9UKN7

Source protein: Unconventional myosin-XV

Source gene: MYO15A

Class: DEG_SCF_SKP2-CKS1_1

Location: 1035:1042

E3 ligase: SKP2,CSK1

DEGRON score: 0.9813

ASA_SCORE: 103.8375

COIL: 0.9514

CONS_SCORE: 0.205

DSS_SCORE: 0.818

HELIX: 0.0264

FCONS_SCORE: 0.8277

RIG_SCORE: 0.5824

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1045A	TCGA-B5-A3FA	UCEC	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.6944
p.T1045A	DO52402	UCEC	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.6944
p.D1037G	TCGA-IB-7651	PAAD	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.7198
p.D1037G	DO46657	PAAD	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.7198
p.D1043N	TCGA-Z2-A8RT	SKCM	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D1043N	DO51301	SKCM	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P1040T	DO23376	LINC	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P1040L	DO222810	MELA	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P1046L	SIDM00189	Melanoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P1046L	ACH-002098	Skin Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P1046L	CP67-MEL	skin	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.V1038I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.5965
p.V1038I	SIDM00200	Ewing's Sarcoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.5965
p.V1038I	ACH-000789	Lung Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.5965
p.P1047R	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00057	Neuroblastoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM01716	Non-Cancerous	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00694	Other Solid Cancers	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00175	Melanoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00849	Kidney Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM01064	Hodgkin's Lymphoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00539	Esophageal Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00988	Kidney Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1047R	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K1048E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K1048E	ACH-001127	Leukemia	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K1048E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K1036E	ACH-001403	Ovarian Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.591
p.V1050I	EW-12	bone	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKDVTPPK

Degron related mutations and impact score

Drug responses associated with MYO15A mutations

All proteins holding degron of PKDVTPPK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN7	Unconventional myosin-XV	DEG_SCF_SKP2-CKS1_1	1035:1042	PKDVTPPK	SKP2,CSK1	0.9813	More...