DegronMD

Uniprot ID: Q9UKN7

Source protein: Unconventional myosin-XV

Source gene: MYO15A

Class: DEG_ODPH_VHL_1

Location: 2521:2534

E3 ligase: VHL

DEGRON score: 0.8036

ASA_SCORE: 97.6286

COIL: 0.941

CONS_SCORE: 0.3006

DSS_SCORE: 0.4692

HELIX: 0.0349

FCONS_SCORE: 1.0311

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2512M	TCGA-28-1746	GBM	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.0833
p.V2512M	TCGA-IB-7651	PAAD	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.0833
p.V2512M	DO13564	GBM	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.0833
p.V2512M	DO46657	PAAD	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.0833
p.V2512M	SIDM01617	Endometrial Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.0833
p.A2527T	TCGA-AP-A0LM	UCEC	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.6028
p.A2527T	DO43306	UCEC	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.6028
p.R2515H	TCGA-B5-A3FC	UCEC	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1667
p.R2515H	DO41871	UCEC	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1667
p.R2515H	SIDM00437	Acute Myeloid Leukemia	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1667
p.R2515H	ACH-000362	Leukemia	CCLE	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1667
p.R2515H	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1667
p.A2538V	TCGA-HU-A4GN	STAD	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.2222
p.A2538V	DO47833	STAD	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.2222
p.L2513I	DO230335	COCA	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1111
p.A2529D	SIDM01137	Pancreatic Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.6682
p.A2529D	ACH-000235	Pancreatic Cancer	CCLE	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.6682
p.A2529D	PANC-04-03	pancreas	COSMIC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.6682
p.A2516V	SIDM01394	Kidney Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN7	Unconventional myosin-XV	DEG_ODPH_VHL_1	2521:2534	LAPAPLAKAPRLPI	VHL	0.8036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons