DegronMD

Uniprot ID: Q9UKN7

Source protein: Unconventional myosin-XV

Source gene: MYO15A

Class: DEG_APCC_DBOX_1

Location: 219:227

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8446

ASA_SCORE: 69.6333

COIL: 0.7743

CONS_SCORE: 0.2456

DSS_SCORE: 0.3185

HELIX: 0.1192

FCONS_SCORE: 0.9255

RIG_SCORE: 0.718

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R220S	TCGA-49-6761	LUAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	0.7427
p.R220S	DO24566	LUAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.7427
p.E211D	TCGA-CK-4951	COAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	0.1111
p.E211D	DO10582	COAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.1111
p.L226F	TCGA-EL-A3GV	THCA	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	0.6981
p.L226F	DO39628	THCA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.6981
p.R220C	TCGA-NH-A6GC	COAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	0.8301
p.R220C	DO50093	COAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.8301
p.P213S	TCGA-WE-A8K6	SKCM	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	0.1667
p.P213S	DO51283	SKCM	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.1667
p.S228F	DO219641	BRCA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.3056
p.G225R	DO233933	GACA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.6457
p.F220S	DO233941	GACA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.7982
p.P211L	DO14262	HNSC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.1111
p.S214L	DO37961	SKCM	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.1944
p.A235V	DO41752	UCEC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.1111
p.A215D	DO41518	UCEC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	0.2222
p.H216Y	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	0.25
p.H216Y	ACH-000521	Lung Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.25
p.H216Y	NCI-H2030	lung	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	0.25
p.Y224C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	SIDM00381	Cervical Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	SIDM01779	Gastric Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	ACH-000761	Gastric Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	ACH-001622	Brain Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	ACH-001669	Leukemia	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	ACH-002020	Cervical Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	ACH-002238	Leukemia	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	SKG-IIIa	cervix	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.Y224C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	0.5976
p.A215V	ACH-000985	Colon/Colorectal Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	0.2222
p.A215V	LS-411N	large_intestine	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRKSLYGLE

Degron related mutations and impact score

Drug responses associated with MYO15A mutations

All proteins holding degron of SRKSLYGLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN7	Unconventional myosin-XV	DEG_APCC_DBOX_1	219:227	SRKSLYGLE	APC,CDC20,FZR1	0.8446	More...