DegronMD - A7E2V4(ZSWIM8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1150H	TCGA-13-1496	OV	TCGA	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7688
p.Y1566C	TCGA-AP-A054	UCEC	TCGA	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.1389
p.Y1566C	DO42256	UCEC	ICGC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.1389
p.S1151I	TCGA-AP-A059	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7341
p.G1101S	TCGA-B5-A3FC	UCEC	TCGA	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.2778
p.A1588T	TCGA-BK-A6W3	UCEC	TCGA	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.1667
p.P1103S	TCGA-DK-A6B6	BLCA	TCGA	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation altering degron motif	0.6752
p.P1103S	DO48576	BLCA	ICGC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation altering degron motif	0.6752
p.R1114H	DO44048	BLCA	ICGC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.1667
p.G1096V	DO229031	LICA	ICGC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.1389
p.D1145H	DO31899	OV	ICGC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2222
p.A1583T	DO50076	UCEC	ICGC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.3056
p.G1096S	DO41871	UCEC	ICGC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.1389
p.S1146I	DO41361	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.25
p.V1584I	SIDM00253	Neuroblastoma	GDSC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.2778
p.V1584I	NB6	autonomic ganglia	COSMIC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.2778
p.P1139H	SIDM00082	Melanoma	GDSC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation blocking phosphorylation signal	0.5
p.P1139H	SK-MEL-2	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation blocking phosphorylation signal	0.5
p.P1162S	SIDM00890	Melanoma	GDSC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.0833
p.P1162S	C32	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.0833
p.P1112L	ACH-000470	Colon/Colorectal Cancer	CCLE	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.2222
p.P1157S	ACH-000580	Skin Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2222
p.P1157S	C32	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2222
p.R1093Q	HT-3	cervix	COSMIC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.0556
p.V1579I	NB6	autonomic ganglia	COSMIC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation altering degron motif	0.7076
p.A1564T	VAL	haematopoietic and lymphoid tissue	COSMIC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.0833
p.Y1586C	GP5d	large intestine	COSMIC	TAVSFPVPSM	DEG_COP1_1	1573:1582	Mutation rewiring degron network	0.2222
p.P1101H	SK-MEL-2	skin	COSMIC	LTPRPE	DEG_SCF_FBW7_2	1103:1108	Mutation rewiring degron network	0.2778

Kaplan plot for ZSWIM8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSWIM8

UniProt ID: A7E2V4

Entrez ID: 23053

Protein name: Zinc finger SWIM domain-containing protein 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSWIM8 in