DegronMD

Uniprot ID: A7E2V4

Source protein: Zinc finger SWIM domain-containing protein 8

Source gene: ZSWIM8

Class: DEG_COP1_1

Location: 1573:1582

E3 ligase: COP1

DEGRON score: 0.7399

ASA_SCORE: 68.88

COIL: 0.8959

CONS_SCORE: 0.3828

DSS_SCORE: 0.1824

HELIX: 0.0281

FCONS_SCORE: 0.9227

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1566C	TCGA-AP-A054	UCEC	TCGA	TAVSFPVPSM	DEG_COP1_1	0.1389
p.Y1566C	DO42256	UCEC	ICGC	TAVSFPVPSM	DEG_COP1_1	0.1389
p.A1588T	TCGA-BK-A6W3	UCEC	TCGA	TAVSFPVPSM	DEG_COP1_1	0.1667
p.A1583T	DO50076	UCEC	ICGC	TAVSFPVPSM	DEG_COP1_1	0.3056
p.V1584I	SIDM00253	Neuroblastoma	GDSC	TAVSFPVPSM	DEG_COP1_1	0.2778
p.V1584I	NB6	autonomic_ganglia	COSMIC	TAVSFPVPSM	DEG_COP1_1	0.2778
p.V1579I	NB6	autonomic_ganglia	COSMIC	TAVSFPVPSM	DEG_COP1_1	0.7076
p.A1564T	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	TAVSFPVPSM	DEG_COP1_1	0.0833
p.Y1586C	GP5d	large_intestine	COSMIC	TAVSFPVPSM	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_COP1_1	1573:1582	TAVSFPVPSM	COP1	0.7399	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons