DegronMD

Uniprot ID: A7E2V4

Source protein: Zinc finger SWIM domain-containing protein 8

Source gene: ZSWIM8

Class: DEG_SCF_FBW7_2

Location: 1103:1108

E3 ligase: FBXW7

DEGRON score: 0.9295

ASA_SCORE: 94.8167

COIL: 0.8913

CONS_SCORE: 0.3898

DSS_SCORE: 0.6611

HELIX: 0.0493

FCONS_SCORE: 1.0295

RIG_SCORE: 0.6562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1101S	TCGA-B5-A3FC	UCEC	TCGA	LTPRPE	DEG_SCF_FBW7_2	0.2778
p.P1103S	TCGA-DK-A6B6	BLCA	TCGA	LTPRPE	DEG_SCF_FBW7_2	0.6752
p.P1103S	DO48576	BLCA	ICGC	LTPRPE	DEG_SCF_FBW7_2	0.6752
p.R1114H	DO44048	BLCA	ICGC	LTPRPE	DEG_SCF_FBW7_2	0.1667
p.G1096V	DO229031	LICA	ICGC	LTPRPE	DEG_SCF_FBW7_2	0.1389
p.G1096S	DO41871	UCEC	ICGC	LTPRPE	DEG_SCF_FBW7_2	0.1389
p.P1112L	ACH-000470	Colon/Colorectal Cancer	CCLE	LTPRPE	DEG_SCF_FBW7_2	0.2222
p.R1093Q	HT-3	cervix	COSMIC	LTPRPE	DEG_SCF_FBW7_2	0.0556
p.P1101H	SK-MEL-2	skin	COSMIC	LTPRPE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SCF_FBW7_2	1103:1108	LTPRPE	FBXW7	0.9295	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons