DegronMD

Uniprot ID: A7E2V4

Source protein: Zinc finger SWIM domain-containing protein 8

Source gene: ZSWIM8

Class: DEG_SPOP_SBC_1

Location: 1149:1153

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 82.24

COIL: 0.9126

CONS_SCORE: 0.5925

DSS_SCORE: 0.6797

HELIX: 0.0514

FCONS_SCORE: 1.2683

RIG_SCORE: 0.602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1150H	TCGA-13-1496	OV	TCGA	PETTS	DEG_SPOP_SBC_1	0.7688
p.S1151I	TCGA-AP-A059	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.7341
p.D1145H	DO31899	OV	ICGC	PETTS	DEG_SPOP_SBC_1	0.2222
p.S1146I	DO41361	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.25
p.P1139H	SIDM00082	Melanoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.5
p.P1139H	SK-MEL-2	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	0.5
p.P1162S	SIDM00890	Melanoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.0833
p.P1162S	C32	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	0.0833
p.P1157S	ACH-000580	Skin Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.2222
p.P1157S	C32	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons