DegronMD - Q8TD55(PLEKHO2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S167F	TCGA-18-3409	LUSC	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation blocking phosphorylation signal	0.6667
p.S167F	DO26444	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation blocking phosphorylation signal	0.6667
p.S488I	TCGA-43-6770	LUSC	TCGA	KRKELVTLY	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.25
p.S488I	DO27644	LUSC	ICGC	KRKELVTLY	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.25
p.P231S	TCGA-A5-A0G2	UCEC	TCGA	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.25
p.P231S	DO41235	UCEC	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.25
p.G227V	TCGA-AA-3713	COAD	TCGA	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.6421
p.G227V	DO8400	COAD	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.6421
p.R229K	TCGA-AP-A0LM	UCEC	TCGA	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.3056
p.R229K	DO43306	UCEC	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.3056
p.S217G	TCGA-AX-A2HC	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6993
p.S217G	DO41572	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6993
p.P206S	TCGA-BF-AAP2	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.P206S	DO219466	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.S164G	TCGA-DI-A1BU	UCEC	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation blocking phosphorylation signal	0.75
p.S164G	DO42023	UCEC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation blocking phosphorylation signal	0.75
p.R172H	TCGA-F4-6570	COAD	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.R172H	DO10443	COAD	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.R172H	DO229051	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.P218S	TCGA-FW-A3R5	SKCM	TCGA	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2222
p.P218S	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.P218S	DO37406	SKCM	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2222
p.P218S	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.P218L	TCGA-FW-A3R5	SKCM	TCGA	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2222
p.P218L	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.P218L	DO37406	SKCM	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2222
p.P218L	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.R151C	DO227997	COCA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.T232I	DO234445	ESAD	ICGC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation blocking phosphorylation signal	0.6667
p.R150Q	DO48270	ESCA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1944
p.R487I	DO228952	LICA	ICGC	KRKELVTLY	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.2778
p.R172L	DO229029	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.R172L	DO229041	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.V145L	DO229045	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0556
p.R150L	DO231141	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1944
p.G148S	DO26467	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1389
p.D168Y	DO52677	MALY	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1944
p.T155M	DO220258	SARC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.6312
p.P153L	DO37519	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2778
p.G147W	DO37591	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.G147W	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.G147W	ACH-000875	Lung Cancer	CCLE	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.G147W	NCI-H2347	lung	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.Q149K	DO38033	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.P209T	SIDM02031	Esophageal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.2222
p.D220G	SIDM00217	Colorectal Carcinoma	GDSC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2778
p.D220G	SIDM00217	Colorectal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.D220G	ACH-000999	Colon/Colorectal Cancer	CCLE	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2778
p.D220G	ACH-000999	Colon/Colorectal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.D220G	SNU-1040	large intestine	COSMIC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation rewiring degron network	0.2778
p.D220G	SNU-1040	large intestine	COSMIC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.L474Q	ACH-002044	Head and Neck Cancer	CCLE	KRKELVTLY	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.25
p.D170G	SNU-1040	large intestine	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1389
p.R151Q	LoVo	large intestine	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.S228I	HCT-15	large intestine	COSMIC	VETPVGE	DEG_SCF_FBW7_2	222:228	Mutation altering degron motif	0.7341
p.N213I	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	PETTS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.728
p.P146L	NCI-H69	lung	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHO2

UniProt ID: Q8TD55

Entrez ID: 80301

Protein name: Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHO2 in