DegronMD

Uniprot ID: Q8TD55

Source protein: Pleckstrin homology domain-containing family O member 2

Source gene: PLEKHO2

Class: DEG_SCF_FBW7_2

Location: 222:228

E3 ligase: FBXW7

DEGRON score: 0.9076

ASA_SCORE: 92.6714

COIL: 0.909

CONS_SCORE: 0.4231

DSS_SCORE: 0.8012

HELIX: 0.027

FCONS_SCORE: 1.0063

RIG_SCORE: 0.6364

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S228I	HCT-15	large_intestine	COSMIC	VETPVGE	DEG_SCF_FBW7_2	0.7341
p.T232I	DO234445	ESAD	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.6667
p.G227V	TCGA-AA-3713	COAD	TCGA	VETPVGE	DEG_SCF_FBW7_2	0.6421
p.G227V	DO8400	COAD	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.6421
p.R229K	TCGA-AP-A0LM	UCEC	TCGA	VETPVGE	DEG_SCF_FBW7_2	0.3056
p.R229K	DO43306	UCEC	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.3056
p.D220G	SIDM00217	Colorectal Carcinoma	GDSC	VETPVGE	DEG_SCF_FBW7_2	0.2778
p.D220G	ACH-000999	Colon/Colorectal Cancer	CCLE	VETPVGE	DEG_SCF_FBW7_2	0.2778
p.D220G	SNU-1040	large_intestine	COSMIC	VETPVGE	DEG_SCF_FBW7_2	0.2778
p.P231S	TCGA-A5-A0G2	UCEC	TCGA	VETPVGE	DEG_SCF_FBW7_2	0.25
p.P231S	DO41235	UCEC	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.25
p.P218S	TCGA-FW-A3R5	SKCM	TCGA	VETPVGE	DEG_SCF_FBW7_2	0.2222
p.P218S	DO37406	SKCM	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.2222
p.P218L	TCGA-FW-A3R5	SKCM	TCGA	VETPVGE	DEG_SCF_FBW7_2	0.2222
p.P218L	DO37406	SKCM	ICGC	VETPVGE	DEG_SCF_FBW7_2	0.2222

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SCF_FBW7_2	222:228	VETPVGE	FBXW7	0.9076	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons