DegronMD

Uniprot ID: Q8TD55

Source protein: Pleckstrin homology domain-containing family O member 2

Source gene: PLEKHO2

Class: DEG_APCC_DBOX_1

Location: 477:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9653

ASA_SCORE: 97.6889

COIL: 0.2903

CONS_SCORE: 0.3792

DSS_SCORE: 0.531

HELIX: 0.675

FCONS_SCORE: 1.2013

RIG_SCORE: 0.7982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S488I	TCGA-43-6770	LUSC	TCGA	KRKELVTLY	DEG_APCC_DBOX_1	0.25
p.S488I	DO27644	LUSC	ICGC	KRKELVTLY	DEG_APCC_DBOX_1	0.25
p.R487I	DO228952	LICA	ICGC	KRKELVTLY	DEG_APCC_DBOX_1	0.2778
p.L474Q	ACH-002044	Head and Neck Cancer	CCLE	KRKELVTLY	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_APCC_DBOX_1	477:485	KRKELVTLY	APC,CDC20,FZR1	0.9653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons