DegronMD

Uniprot ID: Q8TD55

Source protein: Pleckstrin homology domain-containing family O member 2

Source gene: PLEKHO2

Class: DEG_APCC_DBOX_1

Location: 155:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 71.6556

COIL: 0.2752

CONS_SCORE: 0.6083

DSS_SCORE: 0.5545

HELIX: 0.7123

FCONS_SCORE: 1.1069

RIG_SCORE: 0.7558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S167F	TCGA-18-3409	LUSC	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	0.6667
p.S167F	DO26444	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.6667
p.S164G	TCGA-DI-A1BU	UCEC	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	0.75
p.S164G	DO42023	UCEC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.75
p.R172H	TCGA-F4-6570	COAD	TCGA	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833
p.R172H	DO10443	COAD	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833
p.R172H	DO229051	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833
p.R151C	DO227997	COCA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.2222
p.R150Q	DO48270	ESCA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1944
p.R172L	DO229029	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833
p.R172L	DO229041	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833
p.V145L	DO229045	LICA	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0556
p.R150L	DO231141	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1944
p.G148S	DO26467	LUSC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1389
p.D168Y	DO52677	MALY	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1944
p.T155M	DO220258	SARC	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.6312
p.P153L	DO37519	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.2778
p.G147W	DO37591	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1111
p.G147W	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1111
p.G147W	ACH-000875	Lung Cancer	CCLE	TRVHLKEVA	DEG_APCC_DBOX_1	0.1111
p.G147W	NCI-H2347	lung	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1111
p.Q149K	DO38033	SKCM	ICGC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1667
p.D170G	SNU-1040	large_intestine	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	0.1389
p.R151Q	LoVo	large_intestine	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	0.2222
p.P146L	NCI-H69	lung	COSMIC	TRVHLKEVA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_APCC_DBOX_1	155:163	TRVHLKEVA	APC,CDC20,FZR1	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons