DegronMD - O15164(TRIM24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S748F	TCGA-19-5956	GBM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5556
p.S771C	TCGA-91-6830	LUAD	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5833
p.S771F	TCGA-EB-A41A	SKCM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5833
p.S762F	TCGA-EE-A2GC	SKCM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.7982
p.D747N	DO218980	BLCA	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.0833
p.S763Y	DO228098	EOPC	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.712
p.D772Y	DO229008	LICA	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5556
p.D772Y	DO218944	LUAD	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5556
p.S763F	DO37906	SKCM	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.7982
p.S767G	SIDM00136	Colorectal Carcinoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.25
p.S767G	ACH-000552	Colon/Colorectal Cancer	CCLE	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.25
p.S767G	HT-29	large intestine	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.25
p.S771P	SIDM00516	Melanoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5833
p.S771P	MZ7-mel	skin	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation blocking phosphorylation signal	0.5833
p.S762Y	SIDM00685	Glioblastoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.712
p.S762Y	ACH-000819	Brain Cancer	CCLE	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.712
p.S762Y	LN-18	central nervous system	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.712

Kaplan plot for TRIM24 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM24

UniProt ID: O15164

Entrez ID: 8805

Protein name: Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM24 in