DegronMD

Uniprot ID: O15164

Source protein: Transcription intermediary factor 1-alpha

Source gene: TRIM24

Class: DEG_APCC_DBOX_1

Location: 756:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9873

ASA_SCORE: 82.9444

COIL: 0.6741

CONS_SCORE: 0.4139

DSS_SCORE: 0.5046

HELIX: 0.2821

FCONS_SCORE: 1.1285

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S748F	TCGA-19-5956	GBM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	0.5556
p.S771C	TCGA-91-6830	LUAD	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	0.5833
p.S771F	TCGA-EB-A41A	SKCM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	0.5833
p.S762F	TCGA-EE-A2GC	SKCM	TCGA	PRSILTSLL	DEG_APCC_DBOX_1	0.7982
p.D747N	DO218980	BLCA	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	0.0833
p.S763Y	DO228098	EOPC	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	0.712
p.D772Y	DO229008	LICA	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	0.5556
p.D772Y	DO218944	LUAD	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	0.5556
p.S763F	DO37906	SKCM	ICGC	PRSILTSLL	DEG_APCC_DBOX_1	0.7982
p.S767G	SIDM00136	Colorectal Carcinoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	0.25
p.S767G	ACH-000552	Colon/Colorectal Cancer	CCLE	PRSILTSLL	DEG_APCC_DBOX_1	0.25
p.S767G	HT-29	large_intestine	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	0.25
p.S771P	SIDM00516	Melanoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	0.5833
p.S771P	MZ7-mel	skin	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	0.5833
p.S762Y	SIDM00685	Glioblastoma	GDSC	PRSILTSLL	DEG_APCC_DBOX_1	0.712
p.S762Y	ACH-000819	Brain Cancer	CCLE	PRSILTSLL	DEG_APCC_DBOX_1	0.712
p.S762Y	LN-18	central_nervous_system	COSMIC	PRSILTSLL	DEG_APCC_DBOX_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15164	Transcription intermediary factor 1-alpha	DEG_APCC_DBOX_1	756:764	PRSILTSLL	APC,CDC20,FZR1	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons