DegronMD - O15169(AXIN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R382L	TCGA-69-7979	LUAD	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	DO23874	LUAD	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.Q361H	TCGA-A5-A1OF	UCEC	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.Q361H	DO42568	UCEC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.S359R	TCGA-DU-6407	LGG	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.S359R	DO22295	LGG	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.G364E	TCGA-EO-A22T	UCEC	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6087
p.G364E	DO42320	UCEC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6087
p.R382C	TCGA-FW-A3R5	SKCM	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382C	DO37406	SKCM	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R373C	TCGA-VQ-A8P2	STAD	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.3056
p.Q361K	DO229032	LICA	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.I371S	DO231768	LINC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7341
p.Q361R	SIDM01045	Endometrial Carcinoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.Q361R	ACH-000978	Endometrial/Uterine Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.Q361R	EN	endometrium	COSMIC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.V381F	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0833
p.V381F	ACH-000388	Lymphoma	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0833
p.V377A	SIDM00500	Colorectal Carcinoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.V377A	ACH-000959	Colon/Colorectal Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.R365Q	ACH-001407	Bladder Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7329
p.T374M	ACH-001518	Endometrial/Uterine Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.T374M	ACH-002020	Cervical Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778

Kaplan plot for AXIN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AXIN1

UniProt ID: O15169

Entrez ID: 8312

Protein name: Axin-1 (Axis inhibition protein 1) (hAxin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AXIN1 in