DegronMD

Uniprot ID: O15169

Source protein: Axin-1

Source gene: AXIN1

Class: DEG_APCC_DBOX_1

Location: 364:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9598

ASA_SCORE: 85.6444

COIL: 0.9563

CONS_SCORE: 0.4779

DSS_SCORE: 0.4678

HELIX: 0.0162

FCONS_SCORE: 1.0475

RIG_SCORE: 0.6859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R382L	TCGA-69-7979	LUAD	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.0556
p.R382L	DO23874	LUAD	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.0556
p.Q361H	TCGA-A5-A1OF	UCEC	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.Q361H	DO42568	UCEC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.S359R	TCGA-DU-6407	LGG	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.1944
p.S359R	DO22295	LGG	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.1944
p.G364E	TCGA-EO-A22T	UCEC	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.6087
p.G364E	DO42320	UCEC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.6087
p.R382C	TCGA-FW-A3R5	SKCM	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.0556
p.R382C	DO37406	SKCM	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.0556
p.R373C	TCGA-VQ-A8P2	STAD	TCGA	GRVPLPHIP	DEG_APCC_DBOX_1	0.3056
p.Q361K	DO229032	LICA	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.I371S	DO231768	LINC	ICGC	GRVPLPHIP	DEG_APCC_DBOX_1	0.7341
p.Q361R	SIDM01045	Endometrial Carcinoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.Q361R	ACH-000978	Endometrial/Uterine Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.Q361R	EN	endometrium	COSMIC	GRVPLPHIP	DEG_APCC_DBOX_1	0.25
p.V381F	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	0.0833
p.V381F	ACH-000388	Lymphoma	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.0833
p.V377A	SIDM00500	Colorectal Carcinoma	GDSC	GRVPLPHIP	DEG_APCC_DBOX_1	0.1944
p.V377A	ACH-000959	Colon/Colorectal Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.1944
p.R365Q	ACH-001407	Bladder Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.7329
p.T374M	ACH-001518	Endometrial/Uterine Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.2778
p.T374M	ACH-002020	Cervical Cancer	CCLE	GRVPLPHIP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15169	Axin-1	DEG_APCC_DBOX_1	364:372	GRVPLPHIP	APC,CDC20,FZR1	0.9598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons