DegronMD - O15231(ZNF185)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V297L	TCGA-2H-A9GK	ESCA	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.5654
p.P308T	TCGA-AP-A1DK	UCEC	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.0556
p.P308T	DO42033	UCEC	ICGC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.0556
p.M304T	TCGA-DI-A1BU	UCEC	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.M304T	DO42023	UCEC	ICGC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R295H	SIDM01113	Other Sarcomas	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.7133
p.R295H	ACH-000939	Sarcoma	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.7133
p.R295H	SK-UT-1	soft tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.7133
p.R284H	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R284H	SIDM00217	Colorectal Carcinoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R284H	ACH-000999	Colon/Colorectal Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R284H	ACH-002307	Lymphoma	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R284H	SNU-1040	large intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.R284H	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1667
p.L285P	SIDM00077	Oral Cavity Carcinoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.L285P	ACH-001331	Head and Neck Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.L285P	BICR10	upper aerodigestive tract	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.Q286H	ACH-000608	Ovarian Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.2222
p.V306I	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation blocking phosphorylation signal	0.5556
p.R292Q	COLO-792	skin	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.7329
p.R308Q	COLO-792	skin	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.0556
p.G285R	SW962	vulva	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.R296H	SK-UT-1	soft tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.8244
p.S283G	CW-2	large intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1389
p.S302Y	SW13	adrenal gland	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.2222
p.R285H	SNU-1040	large intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.R285H	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.1944
p.G301R	SW962	vulva	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.25
p.L286P	BICR10	upper aerodigestive tract	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.2222
p.P290H	MFE-296	endometrium	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation altering degron motif	0.6583
p.S286Y	SW13	adrenal gland	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	290:298	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF185

UniProt ID: O15231

Entrez ID: 7739

Protein name: Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF185 in