DegronMD

Uniprot ID: O15231

Source protein: Zinc finger protein 185

Source gene: ZNF185

Class: DEG_APCC_DBOX_1

Location: 290:298

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.893

ASA_SCORE: 92.4333

COIL: 0.7949

CONS_SCORE: 0.489

DSS_SCORE: 0.3822

HELIX: 0.058

FCONS_SCORE: 1.0965

RIG_SCORE: 0.7608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V297L	TCGA-2H-A9GK	ESCA	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	0.5654
p.P308T	TCGA-AP-A1DK	UCEC	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	0.0556
p.P308T	DO42033	UCEC	ICGC	PRAGLRLVA	DEG_APCC_DBOX_1	0.0556
p.M304T	TCGA-DI-A1BU	UCEC	TCGA	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.M304T	DO42023	UCEC	ICGC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R295H	SIDM01113	Other Sarcomas	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	0.7133
p.R295H	ACH-000939	Sarcoma	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	0.7133
p.R295H	SK-UT-1	soft_tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.7133
p.R284H	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R284H	SIDM00217	Colorectal Carcinoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R284H	ACH-000999	Colon/Colorectal Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R284H	ACH-002307	Lymphoma	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R284H	SNU-1040	large_intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.R284H	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1667
p.L285P	SIDM00077	Oral Cavity Carcinoma	GDSC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.L285P	ACH-001331	Head and Neck Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.L285P	BICR10	upper_aerodigestive_tract	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.Q286H	ACH-000608	Ovarian Cancer	CCLE	PRAGLRLVA	DEG_APCC_DBOX_1	0.2222
p.V306I	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.5556
p.R292Q	COLO-792	skin	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.7329
p.R308Q	COLO-792	skin	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.0556
p.G285R	SW962	vulva	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.R296H	SK-UT-1	soft_tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.8244
p.S283G	CW-2	large_intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1389
p.S302Y	SW13	adrenal_gland	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.2222
p.R285H	SNU-1040	large_intestine	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.R285H	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.1944
p.G301R	SW962	vulva	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.25
p.L286P	BICR10	upper_aerodigestive_tract	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.2222
p.P290H	MFE-296	endometrium	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.6583
p.S286Y	SW13	adrenal_gland	COSMIC	PRAGLRLVA	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAGLRLVA

Degron related mutations and impact score

Drug responses associated with ZNF185 mutations

All proteins holding degron of PRAGLRLVA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15231	Zinc finger protein 185	DEG_APCC_DBOX_1	290:298	PRAGLRLVA	APC,CDC20,FZR1	0.893	More...