DegronMD - O15235(MRPS12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R47W	TCGA-55-8089	LUAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R47W	DO23690	LUAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.P45L	TCGA-56-A49D	LUSC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.P45L	TCGA-A5-A0G2	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.P45L	DO45475	LUSC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.P45L	DO41235	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.P56L	TCGA-AA-A02K	COAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.6471
p.P56L	DO9812	COAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.6471
p.G60D	TCGA-AX-A1CE	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.6087
p.G60D	DO42280	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.6087
p.P51H	TCGA-CZ-5457	KIRC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.P51H	DO18036	KIRC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.T65M	TCGA-D1-A17B	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.T65M	TCGA-VQ-A8PO	STAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.T65M	DO51773	STAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.T65M	DO43017	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.25
p.R47L	TCGA-EE-A181	SKCM	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R47L	DO37444	SKCM	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R44G	DO228483	BRCA	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM00232	Kidney Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM01005	Acute Myeloid Leukemia	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM00996	Thyroid Gland Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM01433	Kidney Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	NCC021	kidney	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	TE-6	oesophagus	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	8505C	thyroid	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44G	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R68C	DO230326	COCA	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1667
p.R44Q	SIDM01073	Other Blood Cancers	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44Q	ACH-002242	Leukemia	CCLE	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R44Q	HC-1	haematopoietic and lymphoid tissue	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRPS12

UniProt ID: O15235

Entrez ID: 6183

Protein name: 28S ribosomal protein S12, mitochondrial (MRP-S12) (S12mt) (MT-RPS12) (Mitochondrial small ribosomal subunit protein uS12m)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRPS12 in