DegronMD

Uniprot ID: O15235

Source protein: 28S ribosomal protein S12, mitochondrial

Source gene: MRPS12

Class: DEG_APCC_DBOX_1

Location: 54:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5503

ASA_SCORE: 50.4222

COIL: 0.5784

CONS_SCORE: 0.7049

DSS_SCORE: 0.511

HELIX: 0.0508

FCONS_SCORE: 1.0482

RIG_SCORE: 0.7189

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R47W	TCGA-55-8089	LUAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.1389
p.R47W	DO23690	LUAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.1389
p.P45L	TCGA-56-A49D	LUSC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.0833
p.P45L	TCGA-A5-A0G2	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.0833
p.P45L	DO45475	LUSC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0833
p.P45L	DO41235	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0833
p.P56L	TCGA-AA-A02K	COAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.6471
p.P56L	DO9812	COAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.6471
p.G60D	TCGA-AX-A1CE	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.6087
p.G60D	DO42280	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.6087
p.P51H	TCGA-CZ-5457	KIRC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.P51H	DO18036	KIRC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.T65M	TCGA-D1-A17B	UCEC	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.T65M	TCGA-VQ-A8PO	STAD	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.T65M	DO51773	STAD	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.T65M	DO43017	UCEC	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.25
p.R47L	TCGA-EE-A181	SKCM	TCGA	GRPQLKGVV	DEG_APCC_DBOX_1	0.1389
p.R47L	DO37444	SKCM	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.1389
p.R44G	DO228483	BRCA	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM00232	Kidney Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM01005	Acute Myeloid Leukemia	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM00996	Thyroid Gland Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM01433	Kidney Carcinoma	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	NCC021	kidney	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	TE-6	oesophagus	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	8505C	thyroid	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44G	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R68C	DO230326	COCA	ICGC	GRPQLKGVV	DEG_APCC_DBOX_1	0.1667
p.R44Q	SIDM01073	Other Blood Cancers	GDSC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44Q	ACH-002242	Leukemia	CCLE	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556
p.R44Q	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRPQLKGVV	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPQLKGVV

Degron related mutations and impact score

Drug responses associated with MRPS12 mutations

All proteins holding degron of GRPQLKGVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15235	28S ribosomal protein S12, mitochondrial	DEG_APCC_DBOX_1	54:62	GRPQLKGVV	APC,CDC20,FZR1	0.5503	More...