DegronMD - O15254(ACOX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K291E	TCGA-14-1795	GBM	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation blocking ubiquitination signal	0.6111
p.K291E	DO13114	GBM	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation blocking ubiquitination signal	0.6111
p.M277L	TCGA-B6-A0RP	BRCA	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.25
p.M277L	DO2581	BRCA	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.25
p.M277L	SIDM00699	Small Cell Lung Carcinoma	GDSC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.25
p.M277L	ACH-001138	Lung Cancer	CCLE	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.25
p.M277L	NCI-H2141	lung	COSMIC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.25
p.R270H	TCGA-BG-A220	UCEC	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270H	TCGA-CK-4951	COAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270H	DO10582	COAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270H	DO41784	UCEC	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.E283K	TCGA-BR-8078	STAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.591
p.E283K	TCGA-FP-8099	STAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.591
p.E283K	DO38799	STAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.591
p.E283K	DO38288	STAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.591
p.R270S	TCGA-D9-A149	SKCM	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270S	DO37420	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.P289L	TCGA-EY-A215	UCEC	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.2222
p.P289L	DO42665	UCEC	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.2222
p.P289S	TCGA-FS-A1ZK	SKCM	TCGA	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.2222
p.P289S	DO37474	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.2222
p.L273F	DO37782	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.1389
p.R270C	SIDM00189	Melanoma	GDSC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270C	ACH-002098	Skin Cancer	CCLE	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.R270C	CP67-MEL	skin	COSMIC	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation rewiring degron network	0.0556
p.G284D	ACH-000419	Myeloma	CCLE	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.6087
p.G284D	ACH-001541	Myeloma	CCLE	VTPEGT	DEG_SCF_FBW7_1	280:285	Mutation altering degron motif	0.6087

Kaplan plot for ACOX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACOX3

UniProt ID: O15254

Entrez ID: 8310

Protein name: Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACOX3 in