DegronMD

Uniprot ID: O15254

Source protein: Peroxisomal acyl-coenzyme A oxidase 3

Source gene: ACOX3

Class: DEG_SCF_FBW7_1

Location: 280:285

E3 ligase: FBXW7

DEGRON score: 0.5614

ASA_SCORE: 59

COIL: 0.7728

CONS_SCORE: 0.6182

DSS_SCORE: 0.3491

HELIX: 0.0195

FCONS_SCORE: 0.9541

RIG_SCORE: 0.7325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K291E	TCGA-14-1795	GBM	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.6111
p.K291E	DO13114	GBM	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.6111
p.M277L	TCGA-B6-A0RP	BRCA	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.25
p.M277L	DO2581	BRCA	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.25
p.M277L	SIDM00699	Small Cell Lung Carcinoma	GDSC	VTPEGT	DEG_SCF_FBW7_1	0.25
p.M277L	ACH-001138	Lung Cancer	CCLE	VTPEGT	DEG_SCF_FBW7_1	0.25
p.M277L	NCI-H2141	lung	COSMIC	VTPEGT	DEG_SCF_FBW7_1	0.25
p.R270H	TCGA-BG-A220	UCEC	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270H	TCGA-CK-4951	COAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270H	DO10582	COAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270H	DO41784	UCEC	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.E283K	TCGA-BR-8078	STAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.591
p.E283K	TCGA-FP-8099	STAD	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.591
p.E283K	DO38799	STAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.591
p.E283K	DO38288	STAD	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.591
p.R270S	TCGA-D9-A149	SKCM	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270S	DO37420	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.P289L	TCGA-EY-A215	UCEC	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.2222
p.P289L	DO42665	UCEC	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.2222
p.P289S	TCGA-FS-A1ZK	SKCM	TCGA	VTPEGT	DEG_SCF_FBW7_1	0.2222
p.P289S	DO37474	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.2222
p.L273F	DO37782	SKCM	ICGC	VTPEGT	DEG_SCF_FBW7_1	0.1389
p.R270C	SIDM00189	Melanoma	GDSC	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270C	ACH-002098	Skin Cancer	CCLE	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.R270C	CP67-MEL	skin	COSMIC	VTPEGT	DEG_SCF_FBW7_1	0.0556
p.G284D	ACH-000419	Myeloma	CCLE	VTPEGT	DEG_SCF_FBW7_1	0.6087
p.G284D	ACH-001541	Myeloma	CCLE	VTPEGT	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15254	Peroxisomal acyl-coenzyme A oxidase 3	DEG_SCF_FBW7_1	280:285	VTPEGT	FBXW7	0.5614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons