DegronMD - O15259(NPHP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P209S	TCGA-AP-A1DK	UCEC	TCGA	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.6752
p.L201R	TCGA-D9-A6EC	SKCM	TCGA	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1667
p.G216D	TCGA-EB-A24D	SKCM	TCGA	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2222
p.G197V	TCGA-EO-A3B0	UCEC	TCGA	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0556
p.T198I	DO41999	UCEC	ICGC	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0833
p.S211G	SIDM00241	Breast Carcinoma	GDSC	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.5882
p.S211G	ACH-002179	Breast Cancer	CCLE	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.5882
p.S211G	OCUB-M	breast	COSMIC	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.5882
p.T216M	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LEPYSE	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons