DegronMD

Uniprot ID: O15259

Source protein: Nephrocystin-1

Source gene: NPHP1

Class: LIG_APCC_ABBA_1

Location: 207:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7676

ASA_SCORE: 67.2333

COIL: 0.437

CONS_SCORE: 0.3517

DSS_SCORE: 0.6634

HELIX: 0.0742

FCONS_SCORE: 0.8815

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P209S	TCGA-AP-A1DK	UCEC	TCGA	LEPYSE	LIG_APCC_ABBA_1	0.6752
p.L201R	TCGA-D9-A6EC	SKCM	TCGA	LEPYSE	LIG_APCC_ABBA_1	0.1667
p.G216D	TCGA-EB-A24D	SKCM	TCGA	LEPYSE	LIG_APCC_ABBA_1	0.2222
p.G197V	TCGA-EO-A3B0	UCEC	TCGA	LEPYSE	LIG_APCC_ABBA_1	0.0556
p.T198I	DO41999	UCEC	ICGC	LEPYSE	LIG_APCC_ABBA_1	0.0833
p.S211G	SIDM00241	Breast Carcinoma	GDSC	LEPYSE	LIG_APCC_ABBA_1	0.5882
p.S211G	ACH-002179	Breast Cancer	CCLE	LEPYSE	LIG_APCC_ABBA_1	0.5882
p.S211G	OCUB-M	breast	COSMIC	LEPYSE	LIG_APCC_ABBA_1	0.5882
p.T216M	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LEPYSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15259	Nephrocystin-1	LIG_APCC_ABBA_1	207:212	LEPYSE	APC,CDC20,FZR1	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons