DegronMD - O15264(MAPK13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E315K	TCGA-C5-A8XK	CESC	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.E315K	TCGA-D8-A1XJ	BRCA	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.E319K	TCGA-EB-A5UM	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1667
p.P306L	TCGA-EE-A2GI	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.P314T	TCGA-EE-A2MP	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.A300V	TCGA-XK-AAIW	PRAD	TCGA	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.E307Q	DO48436	BLCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.D315N	DO474	BLCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.E309G	DO228246	BRCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.6087
p.E305K	DO5611	BRCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.25
p.E305K	DO49904	CESC	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.25
p.F314S	DO14398	HNSC	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.E309K	DO47282	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.591
p.P304T	DO37818	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2222
p.E321K	DO37782	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.S317F	DO51259	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2222
p.P323L	SIDM02015	Colorectal Carcinoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.0556
p.R312Q	SIDM02013	Colorectal Carcinoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.6218
p.A300T	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.P310T	SIDM00467	Acute Myeloid Leukemia	GDSC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.7031
p.P310T	ACH-002299	Leukemia	CCLE	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.7031
p.P310T	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	FEPFRD	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.7031

Kaplan plot for MAPK13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPK13

UniProt ID: O15264

Entrez ID: 5603

Protein name: Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPK13 in