DegronMD

Uniprot ID: O15264

Source protein: Mitogen-activated protein kinase 13

Source gene: MAPK13

Class: LIG_APCC_ABBA_1

Location: 308:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6604

ASA_SCORE: 57.4833

COIL: 0.6157

CONS_SCORE: 0.7218

DSS_SCORE: 0.6408

HELIX: 0.34

FCONS_SCORE: 1.0074

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E315K	TCGA-C5-A8XK	CESC	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.2778
p.E315K	TCGA-D8-A1XJ	BRCA	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.2778
p.E319K	TCGA-EB-A5UM	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.1667
p.P306L	TCGA-EE-A2GI	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.2778
p.P314T	TCGA-EE-A2MP	SKCM	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.3056
p.A300V	TCGA-XK-AAIW	PRAD	TCGA	FEPFRD	LIG_APCC_ABBA_1	0.1111
p.E307Q	DO48436	BLCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.3056
p.D315N	DO474	BLCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.2778
p.E309G	DO228246	BRCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.6087
p.E305K	DO5611	BRCA	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.25
p.E305K	DO49904	CESC	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.25
p.F314S	DO14398	HNSC	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.3056
p.E309K	DO47282	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.591
p.P304T	DO37818	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.2222
p.E321K	DO37782	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.1111
p.S317F	DO51259	SKCM	ICGC	FEPFRD	LIG_APCC_ABBA_1	0.2222
p.P323L	SIDM02015	Colorectal Carcinoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	0.0556
p.R312Q	SIDM02013	Colorectal Carcinoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	0.6218
p.A300T	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	FEPFRD	LIG_APCC_ABBA_1	0.1111
p.P310T	SIDM00467	Acute Myeloid Leukemia	GDSC	FEPFRD	LIG_APCC_ABBA_1	0.7031
p.P310T	ACH-002299	Leukemia	CCLE	FEPFRD	LIG_APCC_ABBA_1	0.7031
p.P310T	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	FEPFRD	LIG_APCC_ABBA_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15264	Mitogen-activated protein kinase 13	LIG_APCC_ABBA_1	308:313	FEPFRD	APC,CDC20,FZR1	0.6604	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons