DegronMD - O15270(SPTLC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E558Q	TCGA-78-7146	LUAD	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.E558Q	DO23717	LUAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.R543L	TCGA-AA-3664	COAD	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543L	TCGA-CN-6010	HNSC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543L	TCGA-FS-A1Z0	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543L	DO7831	COAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543L	DO14766	HNSC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543L	DO37431	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7316
p.R543W	TCGA-AJ-A3EL	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	TCGA-AN-A046	BRCA	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	TCGA-EO-A22U	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	TCGA-FI-A2D5	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	DO1285	BRCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	DO33084	PACA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	DO41542	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	DO43755	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543W	DO41331	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.7523
p.R543Q	TCGA-C5-A1BM	CESC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.6218
p.R543Q	DO49007	CESC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.6218
p.R543Q	DO230605	PRAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.6218
p.E530K	TCGA-D8-A27G	BRCA	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.E530K	DO5465	BRCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.G532V	TCGA-EE-A20F	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.1111
p.G532V	DO37961	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.1111
p.P546H	TCGA-EE-A2M8	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.6583
p.P546H	DO38075	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation altering degron motif	0.6583
p.D549N	TCGA-GN-A266	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.3056
p.D549N	DO37432	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.3056
p.K538Q	DO218243	GACA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking ubiquitination signal	0.7222
p.E554K	DO228176	PBCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.1667
p.P551L	DO229453	SKCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.25
p.T555M	SIDM00689	B-Lymphoblastic Leukemia	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00074	Burkitt's Lymphoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00717	Non-Cancerous	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00473	Oral Cavity Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM01078	Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00733	Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM00968	Ovarian Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM01000	Melanoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM01085	Bladder Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM01640	Acute Myeloid Leukemia	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.T555M	SIDM01215	Ovarian Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation blocking phosphorylation signal	0.5833
p.E558K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.E558K	ACH-000945	Lung Cancer	CCLE	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556
p.E558K	NCI-H650	lung	COSMIC	SRHRLVPLL	DEG_APCC_DBOX_1	540:548	Mutation rewiring degron network	0.0556

Kaplan plot for SPTLC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTLC2

UniProt ID: O15270

Entrez ID: 9517

Protein name: Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTLC2 in