DegronMD

Uniprot ID: O15270

Source protein: Serine palmitoyltransferase 2

Source gene: SPTLC2

Class: DEG_APCC_DBOX_1

Location: 540:548

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7464

ASA_SCORE: 97.7889

COIL: 0.8852

CONS_SCORE: 0.2032

DSS_SCORE: 0.1742

HELIX: 0.0614

FCONS_SCORE: 0.8408

RIG_SCORE: 0.8098

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E558Q	TCGA-78-7146	LUAD	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.E558Q	DO23717	LUAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.R543L	TCGA-AA-3664	COAD	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543L	TCGA-CN-6010	HNSC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543L	TCGA-FS-A1Z0	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543L	DO7831	COAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543L	DO14766	HNSC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543L	DO37431	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7316
p.R543W	TCGA-AJ-A3EL	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	TCGA-AN-A046	BRCA	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	TCGA-EO-A22U	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	TCGA-FI-A2D5	UCEC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	DO1285	BRCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	DO33084	PACA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	DO41542	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	DO43755	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543W	DO41331	UCEC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7523
p.R543Q	TCGA-C5-A1BM	CESC	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.6218
p.R543Q	DO49007	CESC	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.6218
p.R543Q	DO230605	PRAD	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.6218
p.E530K	TCGA-D8-A27G	BRCA	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.E530K	DO5465	BRCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.G532V	TCGA-EE-A20F	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.1111
p.G532V	DO37961	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.1111
p.P546H	TCGA-EE-A2M8	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.6583
p.P546H	DO38075	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.6583
p.D549N	TCGA-GN-A266	SKCM	TCGA	SRHRLVPLL	DEG_APCC_DBOX_1	0.3056
p.D549N	DO37432	SKCM	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.3056
p.K538Q	DO218243	GACA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.7222
p.E554K	DO228176	PBCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.1667
p.P551L	DO229453	SKCA	ICGC	SRHRLVPLL	DEG_APCC_DBOX_1	0.25
p.T555M	SIDM00689	B-Lymphoblastic Leukemia	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00074	Burkitt's Lymphoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00717	Non-Cancerous	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00473	Oral Cavity Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM01078	Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00733	Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM00968	Ovarian Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM01000	Melanoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM01085	Bladder Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM01640	Acute Myeloid Leukemia	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.T555M	SIDM01215	Ovarian Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.5833
p.E558K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.E558K	ACH-000945	Lung Cancer	CCLE	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556
p.E558K	NCI-H650	lung	COSMIC	SRHRLVPLL	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRHRLVPLL

Degron related mutations and impact score

Drug responses associated with SPTLC2 mutations

All proteins holding degron of SRHRLVPLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15270	Serine palmitoyltransferase 2	DEG_APCC_DBOX_1	540:548	SRHRLVPLL	APC,CDC20,FZR1	0.7464	More...