DegronMD - O15360(FANCA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E698K	TCGA-G2-A3VY	BLCA	TCGA	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.1111
p.E698K	DO590	BLCA	ICGC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.1111
p.R714Q	DO233760	GACA	ICGC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.2778
p.V697F	DO232846	NACA	ICGC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.0833
p.K701E	SIDM00411	Pancreatic Carcinoma	GDSC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation blocking ubiquitination signal	0.6389
p.K701E	YAPC	pancreas	COSMIC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation blocking ubiquitination signal	0.6389
p.V697I	SIDM00636	Non-Cancerous	GDSC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.0833
p.V697I	ACH-002270	Non-Cancerous	CCLE	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.0833
p.V697I	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation rewiring degron network	0.0833
p.P709L	ACH-001194	Kidney Cancer	CCLE	INTPRLE	DEG_SCF_FBW7_2	706:712	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons