DegronMD

Uniprot ID: O15360

Source protein: Fanconi anemia group A protein

Source gene: FANCA

Class: DEG_SCF_FBW7_2

Location: 706:712

E3 ligase: FBXW7

DEGRON score: 0.7564

ASA_SCORE: 75.7571

COIL: 0.845

CONS_SCORE: 0.2433

DSS_SCORE: 0.3266

HELIX: 0.051

FCONS_SCORE: 0.8387

RIG_SCORE: 0.7387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E698K	TCGA-G2-A3VY	BLCA	TCGA	INTPRLE	DEG_SCF_FBW7_2	0.1111
p.E698K	DO590	BLCA	ICGC	INTPRLE	DEG_SCF_FBW7_2	0.1111
p.R714Q	DO233760	GACA	ICGC	INTPRLE	DEG_SCF_FBW7_2	0.2778
p.V697F	DO232846	NACA	ICGC	INTPRLE	DEG_SCF_FBW7_2	0.0833
p.K701E	SIDM00411	Pancreatic Carcinoma	GDSC	INTPRLE	DEG_SCF_FBW7_2	0.6389
p.K701E	YAPC	pancreas	COSMIC	INTPRLE	DEG_SCF_FBW7_2	0.6389
p.V697I	SIDM00636	Non-Cancerous	GDSC	INTPRLE	DEG_SCF_FBW7_2	0.0833
p.V697I	ACH-002270	Non-Cancerous	CCLE	INTPRLE	DEG_SCF_FBW7_2	0.0833
p.V697I	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	INTPRLE	DEG_SCF_FBW7_2	0.0833
p.P709L	ACH-001194	Kidney Cancer	CCLE	INTPRLE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15360	Fanconi anemia group A protein	DEG_SCF_FBW7_2	706:712	INTPRLE	FBXW7	0.7564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons