DegronMD - O15409(FOXP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S453T	TCGA-24-1845	OV	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7116
p.L450M	TCGA-E6-A1LX	UCEC	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.711
p.P465Q	TCGA-EE-A3AA	SKCM	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1111
p.K446N	TCGA-OR-A5KB	ACC	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.25
p.K446N	TCGA-P5-A5EX	LGG	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.25
p.S457W	TCGA-T3-A92M	HNSC	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7874
p.S457L	TCGA-W3-AA1R	SKCM	TCGA	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7667
p.P456L	DO234353	ESAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7582
p.V456I	DO234462	ESAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7076
p.V456I	DO10960	GBM	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7076
p.V456I	DO51495	PACA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7076
p.V456I	DO51776	STAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7076
p.V456I	DO42384	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7076
p.P450S	DO222286	GACA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.6752
p.A452S	DO229018	LICA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7588
p.A467S	DO229026	LICA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0556
p.Q459L	DO218919	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2778
p.T448I	DO218944	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.3056
p.T448I	DO228253	MALY	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.3056
p.G443V	DO23838	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1667
p.N461H	DO52021	LUSC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.N454T	DO52655	MALY	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7055
p.H457Y	DO222599	MELA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7229
p.H457Y	DO37835	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7229
p.P444L	DO222662	MELA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1944
p.I457L	DO46556	OV	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.6063
p.P450L	DO46685	PACA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7582
p.I445M	DO36556	READ	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.H466Y	DO228014	SKCA	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0833
p.P440Q	DO37571	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0833
p.N461I	DO50288	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.N461S	DO38404	STAD	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.A455V	DO43186	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.6936
p.E458K	DO41572	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.3056
p.E458K	DO52426	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.3056
p.N446H	DO42568	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.25
p.P444H	DO41133	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1944
p.S467R	SIDM00677	Colorectal Carcinoma	GDSC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0556
p.S467R	LS-513	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0556
p.S442R	ACH-000007	Colon/Colorectal Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1389
p.S442R	LS-513	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1389
p.T451M	ACH-000946	Endometrial/Uterine Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.6312
p.Q445E	ACH-001416	Bladder Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.T445A	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.R444L	NCI-H1092	lung	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1944
p.N461D	IPC-298	skin	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.M466V	MSTO-211H	pleura	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0833
p.S459R	LS-513	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2778
p.R461Q	RCM-1	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.2222
p.S443R	LS-513	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.1667
p.R457Q	RCM-1	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation altering degron motif	0.7329
p.S439R	LS-513	large intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	449:457	Mutation rewiring degron network	0.0556

Kaplan plot for FOXP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXP2

UniProt ID: O15409

Entrez ID: 93986

Protein name: Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXP2 in