DegronMD

Uniprot ID: O15409

Source protein: Forkhead box protein P2

Source gene: FOXP2

Class: DEG_SIAH_1

Location: 449:457

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9152

ASA_SCORE: 88.2222

COIL: 0.9582

CONS_SCORE: 0.4997

DSS_SCORE: 0.6762

HELIX: 0.0151

FCONS_SCORE: 1.0256

RIG_SCORE: 0.6776

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S453T	TCGA-24-1845	OV	TCGA	TPTAPVTPI	DEG_SIAH_1	0.7116
p.L450M	TCGA-E6-A1LX	UCEC	TCGA	TPTAPVTPI	DEG_SIAH_1	0.711
p.P465Q	TCGA-EE-A3AA	SKCM	TCGA	TPTAPVTPI	DEG_SIAH_1	0.1111
p.K446N	TCGA-OR-A5KB	ACC	TCGA	TPTAPVTPI	DEG_SIAH_1	0.25
p.K446N	TCGA-P5-A5EX	LGG	TCGA	TPTAPVTPI	DEG_SIAH_1	0.25
p.S457W	TCGA-T3-A92M	HNSC	TCGA	TPTAPVTPI	DEG_SIAH_1	0.7874
p.S457L	TCGA-W3-AA1R	SKCM	TCGA	TPTAPVTPI	DEG_SIAH_1	0.7667
p.P456L	DO234353	ESAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7582
p.V456I	DO234462	ESAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7076
p.V456I	DO10960	GBM	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7076
p.V456I	DO51495	PACA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7076
p.V456I	DO51776	STAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7076
p.V456I	DO42384	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7076
p.P450S	DO222286	GACA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.6752
p.A452S	DO229018	LICA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7588
p.A467S	DO229026	LICA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.0556
p.Q459L	DO218919	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.2778
p.T448I	DO218944	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.3056
p.T448I	DO228253	MALY	ICGC	TPTAPVTPI	DEG_SIAH_1	0.3056
p.G443V	DO23838	LUAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.1667
p.N461H	DO52021	LUSC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.N454T	DO52655	MALY	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7055
p.H457Y	DO222599	MELA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7229
p.H457Y	DO37835	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7229
p.P444L	DO222662	MELA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.1944
p.I457L	DO46556	OV	ICGC	TPTAPVTPI	DEG_SIAH_1	0.6063
p.P450L	DO46685	PACA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.7582
p.I445M	DO36556	READ	ICGC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.H466Y	DO228014	SKCA	ICGC	TPTAPVTPI	DEG_SIAH_1	0.0833
p.P440Q	DO37571	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	0.0833
p.N461I	DO50288	SKCM	ICGC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.N461S	DO38404	STAD	ICGC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.A455V	DO43186	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.6936
p.E458K	DO41572	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.3056
p.E458K	DO52426	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.3056
p.N446H	DO42568	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.25
p.P444H	DO41133	UCEC	ICGC	TPTAPVTPI	DEG_SIAH_1	0.1944
p.S467R	SIDM00677	Colorectal Carcinoma	GDSC	TPTAPVTPI	DEG_SIAH_1	0.0556
p.S467R	LS-513	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.0556
p.S442R	ACH-000007	Colon/Colorectal Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	0.1389
p.S442R	LS-513	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.1389
p.T451M	ACH-000946	Endometrial/Uterine Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	0.6312
p.Q445E	ACH-001416	Bladder Cancer	CCLE	TPTAPVTPI	DEG_SIAH_1	0.2222
p.T445A	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.R444L	NCI-H1092	lung	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.1944
p.N461D	IPC-298	skin	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.M466V	MSTO-211H	pleura	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.0833
p.S459R	LS-513	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.2778
p.R461Q	RCM-1	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.2222
p.S443R	LS-513	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.1667
p.R457Q	RCM-1	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.7329
p.S439R	LS-513	large_intestine	COSMIC	TPTAPVTPI	DEG_SIAH_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPTAPVTPI

Degron related mutations and impact score

Drug responses associated with FOXP2 mutations

All proteins holding degron of TPTAPVTPI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15409	Forkhead box protein P2	DEG_SIAH_1	449:457	TPTAPVTPI	SIAH1,SIAH2,SIAH3	0.9152	More...