DegronMD - O15427(SLC16A3)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S464G	TCGA-VQ-A8PP	STAD	TCGA	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.8104
p.S464G	DO51774	STAD	ICGC	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.8104
p.H459Y	TCGA-ZF-A9RG	BLCA	TCGA	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6118
p.H459Y	DO219076	BLCA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6118
p.E456D	DO229035	LICA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.3056
p.E456D	DO229268	THCA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.3056
p.H459N	SIDM00630	Breast Carcinoma	GDSC	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6312
p.H459N	ACH-000876	Breast Cancer	CCLE	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6312
p.P461L	ACH-001130	Lymphoma	CCLE	VVHTPETS	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons