DegronMD

Uniprot ID: O15427

Source protein: Monocarboxylate transporter 4

Source gene: SLC16A3

Class: DEG_SCF_FBW7_1

Location: 457:464

E3 ligase: FBXW7

DEGRON score: 0.93

ASA_SCORE: 86.1375

COIL: 0.7635

CONS_SCORE: 0.307

DSS_SCORE: 0.858

HELIX: 0.0689

FCONS_SCORE: 0.8598

RIG_SCORE: 0.7201

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S464G	TCGA-VQ-A8PP	STAD	TCGA	VVHTPETS	DEG_SCF_FBW7_1	0.8104
p.S464G	DO51774	STAD	ICGC	VVHTPETS	DEG_SCF_FBW7_1	0.8104
p.H459Y	TCGA-ZF-A9RG	BLCA	TCGA	VVHTPETS	DEG_SCF_FBW7_1	0.6118
p.H459Y	DO219076	BLCA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	0.6118
p.E456D	DO229035	LICA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	0.3056
p.E456D	DO229268	THCA	ICGC	VVHTPETS	DEG_SCF_FBW7_1	0.3056
p.H459N	SIDM00630	Breast Carcinoma	GDSC	VVHTPETS	DEG_SCF_FBW7_1	0.6312
p.H459N	ACH-000876	Breast Cancer	CCLE	VVHTPETS	DEG_SCF_FBW7_1	0.6312
p.P461L	ACH-001130	Lymphoma	CCLE	VVHTPETS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15427	Monocarboxylate transporter 4	DEG_SCF_FBW7_1	457:464	VVHTPETS	FBXW7	0.93	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons