DegronMD - O15460(P4HA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W333S	TCGA-78-7158	LUAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.2222
p.W333S	DO24729	LUAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.2222
p.P336T	TCGA-AN-A0AK	BRCA	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.P336T	DO1608	BRCA	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.E332K	TCGA-AX-A05Z	UCEC	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.E332K	DO40884	UCEC	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.E332K	SIDM00835	Colorectal Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.E332K	ACH-000489	Colon/Colorectal Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.E332K	SW1116	large intestine	COSMIC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.V339I	TCGA-B7-5816	STAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	TCGA-BR-4292	STAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	DO38599	STAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	DO38495	STAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	SIDM00668	Non-Cancerous	GDSC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	ACH-002245	Lymphoma	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.V339I	Hs-445	haematopoietic and lymphoid tissue	COSMIC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0556
p.P336S	TCGA-GN-A26C	SKCM	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.P336S	DO37782	SKCM	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.E332Q	TCGA-KU-A66S	HNSC	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.E332Q	DO44456	HNSC	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.Q321H	TCGA-L9-A8F4	LUAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.Q321H	DO49876	LUAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.25
p.R318M	TCGA-XK-AAIW	PRAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1667
p.R318M	DO51407	PRAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1667
p.H337Q	DO229009	LICA	ICGC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1111
p.P336L	SIDM00889	Cervical Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.P336L	ACH-001333	Cervical Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.P336L	C-33-A	cervix	COSMIC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1389
p.H315R	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.H315R	SIDM00217	Colorectal Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.H315R	ACH-000999	Colon/Colorectal Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.H315R	ACH-002392	Lymphoma	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.H315R	SNU-1040	large intestine	COSMIC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.H315R	SC-1	haematopoietic and lymphoid tissue	COSMIC	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.0833
p.S335N	ACH-001551	Skin Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	324:329	Mutation rewiring degron network	0.1667

Kaplan plot for P4HA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P4HA2

UniProt ID: O15460

Entrez ID: 8974

Protein name: Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P4HA2 in