DegronMD

Uniprot ID: O15460

Source protein: Prolyl 4-hydroxylase subunit alpha-2

Source gene: P4HA2

Class: LIG_APCC_ABBA_1

Location: 324:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5261

ASA_SCORE: 63.4

COIL: 0.6082

CONS_SCORE: 0.4859

DSS_SCORE: 0.3575

HELIX: 0.1027

FCONS_SCORE: 0.9818

RIG_SCORE: 0.7832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W333S	TCGA-78-7158	LUAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.2222
p.W333S	DO24729	LUAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.2222
p.P336T	TCGA-AN-A0AK	BRCA	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.P336T	DO1608	BRCA	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.E332K	TCGA-AX-A05Z	UCEC	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.25
p.E332K	DO40884	UCEC	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.25
p.E332K	SIDM00835	Colorectal Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	0.25
p.E332K	ACH-000489	Colon/Colorectal Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.25
p.E332K	SW1116	large_intestine	COSMIC	IAPFKE	LIG_APCC_ABBA_1	0.25
p.V339I	TCGA-B7-5816	STAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	TCGA-BR-4292	STAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	DO38599	STAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	DO38495	STAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	SIDM00668	Non-Cancerous	GDSC	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	ACH-002245	Lymphoma	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.V339I	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	IAPFKE	LIG_APCC_ABBA_1	0.0556
p.P336S	TCGA-GN-A26C	SKCM	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.P336S	DO37782	SKCM	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.E332Q	TCGA-KU-A66S	HNSC	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.25
p.E332Q	DO44456	HNSC	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.25
p.Q321H	TCGA-L9-A8F4	LUAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.25
p.Q321H	DO49876	LUAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.25
p.R318M	TCGA-XK-AAIW	PRAD	TCGA	IAPFKE	LIG_APCC_ABBA_1	0.1667
p.R318M	DO51407	PRAD	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.1667
p.H337Q	DO229009	LICA	ICGC	IAPFKE	LIG_APCC_ABBA_1	0.1111
p.P336L	SIDM00889	Cervical Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.P336L	ACH-001333	Cervical Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.P336L	C-33-A	cervix	COSMIC	IAPFKE	LIG_APCC_ABBA_1	0.1389
p.H315R	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.H315R	SIDM00217	Colorectal Carcinoma	GDSC	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.H315R	ACH-000999	Colon/Colorectal Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.H315R	ACH-002392	Lymphoma	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.H315R	SNU-1040	large_intestine	COSMIC	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.H315R	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IAPFKE	LIG_APCC_ABBA_1	0.0833
p.S335N	ACH-001551	Skin Cancer	CCLE	IAPFKE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPFKE

Degron related mutations and impact score

Drug responses associated with P4HA2 mutations

All proteins holding degron of IAPFKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15460	Prolyl 4-hydroxylase subunit alpha-2	LIG_APCC_ABBA_1	324:329	IAPFKE	APC,CDC20,FZR1	0.5261	More...