DegronMD - O43175(PHGDH)

PHGDH

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A255V	TCGA-A5-A0G2	UCEC	TCGA	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.2222
p.A255V	DO41235	UCEC	ICGC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.2222
p.E265Q	TCGA-DK-AA6L	BLCA	TCGA	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.3056
p.E265Q	DO219002	BLCA	ICGC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.3056
p.C254Y	TCGA-EY-A1GU	UCEC	TCGA	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1944
p.C254Y	DO41518	UCEC	ICGC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1944
p.D274Y	DO228986	LICA	ICGC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.0556
p.A255P	DO48761	LIRI	ICGC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.2222
p.R270W	SIDM00611	Kidney Carcinoma	GDSC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1667
p.R270W	KMRC-1	kidney	COSMIC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1667
p.E264K	SIDM00150	Colorectal Carcinoma	GDSC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.7022
p.E264K	ACH-000969	Colon/Colorectal Cancer	CCLE	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.7022
p.E264K	KM12	large intestine	COSMIC	LDVFTE	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.7022

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*NOTE: the Kaplan plots were collected from OncoLnc