DegronMD

Uniprot ID: O43175

Source protein: D-3-phosphoglycerate dehydrogenase

Source gene: PHGDH

Class: LIG_APCC_ABBA_1

Location: 259:264

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6572

ASA_SCORE: 44.1667

COIL: 0.5522

CONS_SCORE: 0.6576

DSS_SCORE: 0.3802

HELIX: 0.0318

FCONS_SCORE: 1.299

RIG_SCORE: 0.8085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A255V	TCGA-A5-A0G2	UCEC	TCGA	LDVFTE	LIG_APCC_ABBA_1	0.2222
p.A255V	DO41235	UCEC	ICGC	LDVFTE	LIG_APCC_ABBA_1	0.2222
p.E265Q	TCGA-DK-AA6L	BLCA	TCGA	LDVFTE	LIG_APCC_ABBA_1	0.3056
p.E265Q	DO219002	BLCA	ICGC	LDVFTE	LIG_APCC_ABBA_1	0.3056
p.C254Y	TCGA-EY-A1GU	UCEC	TCGA	LDVFTE	LIG_APCC_ABBA_1	0.1944
p.C254Y	DO41518	UCEC	ICGC	LDVFTE	LIG_APCC_ABBA_1	0.1944
p.D274Y	DO228986	LICA	ICGC	LDVFTE	LIG_APCC_ABBA_1	0.0556
p.A255P	DO48761	LIRI	ICGC	LDVFTE	LIG_APCC_ABBA_1	0.2222
p.R270W	SIDM00611	Kidney Carcinoma	GDSC	LDVFTE	LIG_APCC_ABBA_1	0.1667
p.R270W	KMRC-1	kidney	COSMIC	LDVFTE	LIG_APCC_ABBA_1	0.1667
p.E264K	SIDM00150	Colorectal Carcinoma	GDSC	LDVFTE	LIG_APCC_ABBA_1	0.7022
p.E264K	ACH-000969	Colon/Colorectal Cancer	CCLE	LDVFTE	LIG_APCC_ABBA_1	0.7022
p.E264K	KM12	large_intestine	COSMIC	LDVFTE	LIG_APCC_ABBA_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43175	D-3-phosphoglycerate dehydrogenase	LIG_APCC_ABBA_1	259:264	LDVFTE	APC,CDC20,FZR1	0.6572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons