DegronMD - O43264(ZW10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P434S	TCGA-AX-A06F	UCEC	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.6752
p.P434S	DO41752	UCEC	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.6752
p.D442V	TCGA-BR-8487	STAD	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1667
p.D442V	DO47867	STAD	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1667
p.E441K	TCGA-CQ-5326	HNSC	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1944
p.E441K	DO15286	HNSC	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1944
p.I419M	TCGA-DM-A1HB	COAD	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.0833
p.S429Y	TCGA-F5-6814	READ	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.712
p.S429Y	DO36556	READ	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.712
p.H420Q	TCGA-FU-A3EO	CESC	TCGA	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1111
p.H420Q	DO6287	CESC	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation rewiring degron network	0.1111
p.N432S	DO222848	BTCA	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.5958
p.K424R	DO44798	LICA	ICGC	DSKINVPEL	DEG_COP1_1	428:436	Mutation blocking ubiquitination signal	0.6667
p.N432K	SIDM00820	Kidney Carcinoma	GDSC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.5806
p.N432K	SIDM00327	Hodgkin's Lymphoma	GDSC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.5806
p.N432K	L-428	haematopoietic and lymphoid tissue	COSMIC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.5806
p.N432K	RCC-ER	kidney	COSMIC	DSKINVPEL	DEG_COP1_1	428:436	Mutation altering degron motif	0.5806

Kaplan plot for ZW10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZW10

UniProt ID: O43264

Entrez ID: 9183

Protein name: Centromere/kinetochore protein zw10 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZW10 in