DegronMD

Uniprot ID: O43264

Source protein: Centromere/kinetochore protein zw10 homolog

Source gene: ZW10

Class: DEG_COP1_1

Location: 428:436

E3 ligase: COP1

DEGRON score: 0.995

ASA_SCORE: 74.1111

COIL: 0.84

CONS_SCORE: 0.3377

DSS_SCORE: 0.4599

HELIX: 0.0724

FCONS_SCORE: 1.0181

RIG_SCORE: 0.7272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P434S	TCGA-AX-A06F	UCEC	TCGA	DSKINVPEL	DEG_COP1_1	0.6752
p.P434S	DO41752	UCEC	ICGC	DSKINVPEL	DEG_COP1_1	0.6752
p.D442V	TCGA-BR-8487	STAD	TCGA	DSKINVPEL	DEG_COP1_1	0.1667
p.D442V	DO47867	STAD	ICGC	DSKINVPEL	DEG_COP1_1	0.1667
p.E441K	TCGA-CQ-5326	HNSC	TCGA	DSKINVPEL	DEG_COP1_1	0.1944
p.E441K	DO15286	HNSC	ICGC	DSKINVPEL	DEG_COP1_1	0.1944
p.I419M	TCGA-DM-A1HB	COAD	TCGA	DSKINVPEL	DEG_COP1_1	0.0833
p.S429Y	TCGA-F5-6814	READ	TCGA	DSKINVPEL	DEG_COP1_1	0.712
p.S429Y	DO36556	READ	ICGC	DSKINVPEL	DEG_COP1_1	0.712
p.H420Q	TCGA-FU-A3EO	CESC	TCGA	DSKINVPEL	DEG_COP1_1	0.1111
p.H420Q	DO6287	CESC	ICGC	DSKINVPEL	DEG_COP1_1	0.1111
p.N432S	DO222848	BTCA	ICGC	DSKINVPEL	DEG_COP1_1	0.5958
p.K424R	DO44798	LICA	ICGC	DSKINVPEL	DEG_COP1_1	0.6667
p.N432K	SIDM00820	Kidney Carcinoma	GDSC	DSKINVPEL	DEG_COP1_1	0.5806
p.N432K	SIDM00327	Hodgkin's Lymphoma	GDSC	DSKINVPEL	DEG_COP1_1	0.5806
p.N432K	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	DSKINVPEL	DEG_COP1_1	0.5806
p.N432K	RCC-ER	kidney	COSMIC	DSKINVPEL	DEG_COP1_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43264	Centromere/kinetochore protein zw10 homolog	DEG_COP1_1	428:436	DSKINVPEL	COP1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons