DegronMD - O43543(XRCC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R17Q	TCGA-DU-6392	LGG	TCGA	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.R17Q	DO22237	LGG	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.S37L	TCGA-F5-6814	READ	TCGA	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.S37L	DO36556	READ	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.L24F	DO228246	BRCA	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.6981
p.T12N	DO229024	LICA	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation blocking phosphorylation signal	0.5556
p.A33T	SIDM00985	Burkitt's Lymphoma	GDSC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1944
p.A33T	ACH-000245	Lymphoma	CCLE	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1944
p.A33T	BL-41	haematopoietic and lymphoid tissue	COSMIC	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1944
p.S10F	ACH-001694	Head and Neck Cancer	CCLE	GRSSLKEIE	DEG_APCC_DBOX_1	20:28	Mutation blocking phosphorylation signal	0.5

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons