DegronMD

Uniprot ID: O43543

Source protein: DNA repair protein XRCC2

Source gene: XRCC2

Class: DEG_APCC_DBOX_1

Location: 20:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9024

ASA_SCORE: 60.7222

COIL: 0.7008

CONS_SCORE: 0.4252

DSS_SCORE: 0.4187

HELIX: 0.2172

FCONS_SCORE: 0.9348

RIG_SCORE: 0.7235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R17Q	TCGA-DU-6392	LGG	TCGA	GRSSLKEIE	DEG_APCC_DBOX_1	0.25
p.R17Q	DO22237	LGG	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	0.25
p.S37L	TCGA-F5-6814	READ	TCGA	GRSSLKEIE	DEG_APCC_DBOX_1	0.0833
p.S37L	DO36556	READ	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	0.0833
p.L24F	DO228246	BRCA	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	0.6981
p.T12N	DO229024	LICA	ICGC	GRSSLKEIE	DEG_APCC_DBOX_1	0.5556
p.A33T	SIDM00985	Burkitt's Lymphoma	GDSC	GRSSLKEIE	DEG_APCC_DBOX_1	0.1944
p.A33T	ACH-000245	Lymphoma	CCLE	GRSSLKEIE	DEG_APCC_DBOX_1	0.1944
p.A33T	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	GRSSLKEIE	DEG_APCC_DBOX_1	0.1944
p.S10F	ACH-001694	Head and Neck Cancer	CCLE	GRSSLKEIE	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43543	DNA repair protein XRCC2	DEG_APCC_DBOX_1	20:28	GRSSLKEIE	APC,CDC20,FZR1	0.9024	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons