DegronMD - O43556(SGCE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R263C	TCGA-AP-A1DV	UCEC	TCGA	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.25
p.R263C	ACH-000762	Head and Neck Cancer	CCLE	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.25
p.I273M	TCGA-EO-A22X	UCEC	TCGA	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.7618
p.S266Y	DO222884	COCA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.712
p.S266Y	LC-1-sq	lung	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.712
p.P283T	DO228974	LICA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.0556
p.S264A	DO46360	OV	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.2778
p.Y260C	DO36556	READ	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation substituting flanking lysine	0.2778
p.Y273C	DO228013	SKCA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.7087
p.P267S	SIDM00545	Melanoma	GDSC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.6752
p.P267S	Mewo	skin	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.6752
p.V266A	SIDM00193	Colorectal Carcinoma	GDSC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.6936
p.V266A	SNU-81	large intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.6936
p.D259N	ACH-000977	lymph node	CCLE	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.1389
p.D259N	LNCaP-Clone-FGC	prostate	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.1389
p.S276R	GCIY	stomach	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.25
p.V257A	SNU-81	large intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation blocking phosphorylation signal	0.5278
p.S271R	GCIY	stomach	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.7427
p.P258S	Mewo	skin	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.1111
p.D271E	NCI-H508	large intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation altering degron motif	0.6758
p.E279Q	PL-21	haematopoietic and lymphoid tissue	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.1667
p.E280Q	PL-21	haematopoietic and lymphoid tissue	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation blocking ubiquitination signal	0.5833
p.D281N	LNCaP-Clone-FGC	prostate	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	266:273	Mutation rewiring degron network	0.1111

Kaplan plot for SGCE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGCE

UniProt ID: O43556

Entrez ID: 8910

Protein name: Epsilon-sarcoglycan (Epsilon-SG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGCE in