DegronMD

Uniprot ID: O43556

Source protein: Epsilon-sarcoglycan

Source gene: SGCE

Class: DEG_MDM2_SWIB_1

Location: 266:273

E3 ligase: MDM2

DEGRON score: 0.6822

ASA_SCORE: 34.625

COIL: 0.335

CONS_SCORE: 0.6068

DSS_SCORE: 0.0491

HELIX: 0.098

FCONS_SCORE: 1.406

RIG_SCORE: 1.0012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R263C	TCGA-AP-A1DV	UCEC	TCGA	FYIDWCKI	DEG_MDM2_SWIB_1	0.25
p.R263C	ACH-000762	Head and Neck Cancer	CCLE	FYIDWCKI	DEG_MDM2_SWIB_1	0.25
p.I273M	TCGA-EO-A22X	UCEC	TCGA	FYIDWCKI	DEG_MDM2_SWIB_1	0.7618
p.S266Y	DO222884	COCA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	0.712
p.S266Y	LC-1-sq	lung	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.712
p.P283T	DO228974	LICA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	0.0556
p.S264A	DO46360	OV	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	0.2778
p.Y260C	DO36556	READ	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	0.2778
p.Y273C	DO228013	SKCA	ICGC	FYIDWCKI	DEG_MDM2_SWIB_1	0.7087
p.P267S	SIDM00545	Melanoma	GDSC	FYIDWCKI	DEG_MDM2_SWIB_1	0.6752
p.P267S	Mewo	skin	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.6752
p.V266A	SIDM00193	Colorectal Carcinoma	GDSC	FYIDWCKI	DEG_MDM2_SWIB_1	0.6936
p.V266A	SNU-81	large_intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.6936
p.D259N	ACH-000977	lymph_node	CCLE	FYIDWCKI	DEG_MDM2_SWIB_1	0.1389
p.D259N	LNCaP-Clone-FGC	prostate	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.1389
p.S276R	GCIY	stomach	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.25
p.V257A	SNU-81	large_intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.5278
p.S271R	GCIY	stomach	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.7427
p.P258S	Mewo	skin	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.1111
p.D271E	NCI-H508	large_intestine	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.6758
p.E279Q	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.1667
p.E280Q	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.5833
p.D281N	LNCaP-Clone-FGC	prostate	COSMIC	FYIDWCKI	DEG_MDM2_SWIB_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43556	Epsilon-sarcoglycan	DEG_MDM2_SWIB_1	266:273	FYIDWCKI	MDM2	0.6822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons