DegronMD - O43581(SYT7)

FUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N72S	TCGA-17-Z055	LUAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.2778
p.R65H	TCGA-19-5956	GBM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.7133
p.R65H	DO13863	GBM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.7133
p.D60N	TCGA-97-7547	LUAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.6932
p.D60N	DO23594	LUAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.6932
p.K50N	TCGA-A5-A2K5	UCEC	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.1667
p.K50N	DO222798	COCA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.1667
p.K50N	DO41379	UCEC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.1667
p.T55M	TCGA-AA-3831	COAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.1944
p.T55M	DO8538	COAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.1944
p.T55M	DO233259	GACA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.1944
p.K69T	TCGA-BR-8285	STAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.3611
p.K69T	DO38479	STAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation substituting flanking lysine	0.3611
p.S52F	TCGA-GF-A6C9	SKCM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation blocking phosphorylation signal	0.5556
p.S52F	TCGA-GN-A268	SKCM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation blocking phosphorylation signal	0.5556
p.S52F	DO37477	SKCM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation blocking phosphorylation signal	0.5556
p.S52F	DO51254	SKCM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation blocking phosphorylation signal	0.5556
p.V56M	TCGA-HU-A4H3	STAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.2222
p.V56M	DO47903	STAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.2222
p.D75E	DO228069	EOPC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.0833
p.D60E	DO229022	LICA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.6758
p.D73N	DO43154	UCEC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.1389
p.S66G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.6993
p.S66G	ACH-000786	Lymphoma	CCLE	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation altering degron motif	0.6993
p.A75V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGRGRS	DEG_SCF_TRCP1_1	60:66	Mutation rewiring degron network	0.0833

Kaplan plot for SYT7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT7

UniProt ID: O43581

Entrez ID: 9066

Protein name: Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT7 in