DegronMD

Uniprot ID: O43581

Source protein: Synaptotagmin-7

Source gene: SYT7

Class: DEG_SCF_TRCP1_1

Location: 60:66

E3 ligase: BTRC

DEGRON score: 0.6854

ASA_SCORE: 85.6857

COIL: 0.8754

CONS_SCORE: 0.3584

DSS_SCORE: 0.5899

HELIX: 0.0726

FCONS_SCORE: 1.0199

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N72S	TCGA-17-Z055	LUAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.2778
p.R65H	TCGA-19-5956	GBM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.7133
p.R65H	DO13863	GBM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.7133
p.D60N	TCGA-97-7547	LUAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.6932
p.D60N	DO23594	LUAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.6932
p.K50N	TCGA-A5-A2K5	UCEC	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.1667
p.K50N	DO222798	COCA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.1667
p.K50N	DO41379	UCEC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.1667
p.T55M	TCGA-AA-3831	COAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.1944
p.T55M	DO8538	COAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.1944
p.T55M	DO233259	GACA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.1944
p.K69T	TCGA-BR-8285	STAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.3611
p.K69T	DO38479	STAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.3611
p.S52F	TCGA-GF-A6C9	SKCM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.5556
p.S52F	TCGA-GN-A268	SKCM	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.5556
p.S52F	DO37477	SKCM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.5556
p.S52F	DO51254	SKCM	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.5556
p.V56M	TCGA-HU-A4H3	STAD	TCGA	DSGRGRS	DEG_SCF_TRCP1_1	0.2222
p.V56M	DO47903	STAD	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.2222
p.D75E	DO228069	EOPC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.0833
p.D60E	DO229022	LICA	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.6758
p.D73N	DO43154	UCEC	ICGC	DSGRGRS	DEG_SCF_TRCP1_1	0.1389
p.S66G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGRS	DEG_SCF_TRCP1_1	0.6993
p.S66G	ACH-000786	Lymphoma	CCLE	DSGRGRS	DEG_SCF_TRCP1_1	0.6993
p.A75V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGRS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43581	Synaptotagmin-7	DEG_SCF_TRCP1_1	60:66	DSGRGRS	BTRC	0.6854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons