DegronMD - O43597(SPRY2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R64I	TCGA-05-4410	LUAD	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.1944
p.R64I	DO233652	GACA	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.1944
p.R64I	DO25426	LUAD	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.1944
p.S42Y	TCGA-06-5416	GBM	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation blocking phosphorylation signal	0.5278
p.S42Y	TCGA-AP-A1E0	UCEC	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation blocking phosphorylation signal	0.5278
p.S42Y	DO10880	GBM	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation blocking phosphorylation signal	0.5278
p.S42Y	DO43154	UCEC	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation blocking phosphorylation signal	0.5278
p.V62I	TCGA-24-1436	OV	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.25
p.V62I	DO32656	OV	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.25
p.A48G	TCGA-37-4141	LUSC	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.25
p.A48G	DO26862	LUSC	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.25
p.E57G	TCGA-BS-A0U8	UCEC	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.6087
p.E57G	DO41380	UCEC	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.6087
p.G58W	TCGA-RC-A7SF	LIHC	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.6714
p.G58W	DO52311	LIHC	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.6714
p.R50Q	TCGA-XF-A9SP	BLCA	TCGA	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.3056
p.R50Q	DO223598	BLCA	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.3056
p.P63L	DO222662	MELA	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.2222
p.P59L	DO222880	MELA	ICGC	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.7582
p.N53S	SIDM01307	Colorectal Carcinoma	GDSC	NTNEYTEGP	CBL_PTK	51:59	Mutation altering degron motif	0.5958
p.R50P	ACH-002396	Bone Cancer	CCLE	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.3056
p.R50P	Sarc9371	bone	COSMIC	NTNEYTEGP	CBL_PTK	51:59	Mutation rewiring degron network	0.3056

Kaplan plot for SPRY2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRY2

UniProt ID: O43597

Entrez ID: 10253

Protein name: Protein sprouty homolog 2 (Spry-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRY2 in