DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NTNEYTEGP
Uniprot ID:
O43597
Source protein:
Protein sprouty homolog 2
Source gene:
SPRY2
Class:
CBL_PTK
Location:
51:59
E3 ligase:
CBL
DEGRON score:
0.9961
ASA_SCORE:
82.6111
COIL:
0.9174
CONS_SCORE:
0.5216
DSS_SCORE:
0.5765
HELIX:
0.0392
FCONS_SCORE:
1.1
RIG_SCORE:
0.6813
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R64I
TCGA-05-4410
LUAD
TCGA
NTNEYTEGP
CBL_PTK
0.1944
p.R64I
DO233652
GACA
ICGC
NTNEYTEGP
CBL_PTK
0.1944
p.R64I
DO25426
LUAD
ICGC
NTNEYTEGP
CBL_PTK
0.1944
p.S42Y
TCGA-06-5416
GBM
TCGA
NTNEYTEGP
CBL_PTK
0.5278
p.S42Y
TCGA-AP-A1E0
UCEC
TCGA
NTNEYTEGP
CBL_PTK
0.5278
p.S42Y
DO10880
GBM
ICGC
NTNEYTEGP
CBL_PTK
0.5278
p.S42Y
DO43154
UCEC
ICGC
NTNEYTEGP
CBL_PTK
0.5278
p.V62I
TCGA-24-1436
OV
TCGA
NTNEYTEGP
CBL_PTK
0.25
p.V62I
DO32656
OV
ICGC
NTNEYTEGP
CBL_PTK
0.25
p.A48G
TCGA-37-4141
LUSC
TCGA
NTNEYTEGP
CBL_PTK
0.25
p.A48G
DO26862
LUSC
ICGC
NTNEYTEGP
CBL_PTK
0.25
p.E57G
TCGA-BS-A0U8
UCEC
TCGA
NTNEYTEGP
CBL_PTK
0.6087
p.E57G
DO41380
UCEC
ICGC
NTNEYTEGP
CBL_PTK
0.6087
p.G58W
TCGA-RC-A7SF
LIHC
TCGA
NTNEYTEGP
CBL_PTK
0.6714
p.G58W
DO52311
LIHC
ICGC
NTNEYTEGP
CBL_PTK
0.6714
p.R50Q
TCGA-XF-A9SP
BLCA
TCGA
NTNEYTEGP
CBL_PTK
0.3056
p.R50Q
DO223598
BLCA
ICGC
NTNEYTEGP
CBL_PTK
0.3056
p.P63L
DO222662
MELA
ICGC
NTNEYTEGP
CBL_PTK
0.2222
p.P59L
DO222880
MELA
ICGC
NTNEYTEGP
CBL_PTK
0.7582
p.N53S
SIDM01307
Colorectal Carcinoma
GDSC
NTNEYTEGP
CBL_PTK
0.5958
p.R50P
ACH-002396
Bone Cancer
CCLE
NTNEYTEGP
CBL_PTK
0.3056
p.R50P
Sarc9371
bone
COSMIC
NTNEYTEGP
CBL_PTK
0.3056
Drug responses associated with SPRY2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NTNEYTEGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43597
Protein sprouty homolog 2
CBL_PTK
51:59
NTNEYTEGP
CBL
0.9961
More...