DegronMD - O43602(DCX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L301V	TCGA-33-AASL	LUSC	TCGA	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.1111
p.L301V	DO219133	LUSC	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.1111
p.F288C	TCGA-AA-3984	COAD	TCGA	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation altering degron motif	0.7108
p.F288C	DO9002	COAD	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation altering degron motif	0.7108
p.E302K	TCGA-EE-A2GR	SKCM	TCGA	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.0833
p.E302K	DO37996	SKCM	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.0833
p.I295M	TCGA-TN-A7HL	HNSC	TCGA	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778
p.I295M	DO219080	HNSC	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778
p.K283T	DO50316	ESAD	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.1944
p.T303I	DO222420	MELA	ICGC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.0556
p.K285N	SIDM00583	Pancreatic Carcinoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation substituting flanking lysine	0.3611
p.K285N	ACH-001107	Pancreatic Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation substituting flanking lysine	0.3611
p.K285N	KP-1N	pancreas	COSMIC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation substituting flanking lysine	0.3611
p.P288S	SIDM00394	Cervical Carcinoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation altering degron motif	0.6752
p.P288S	ACH-001650	Cervical Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation altering degron motif	0.6752
p.P288S	SISO	cervix	COSMIC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation altering degron motif	0.6752
p.A286S	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778
p.A286S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778
p.S294L	SIDM01059	Melanoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.3056
p.S294L	ACH-000915	Skin Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.3056
p.S294L	IPC-298	skin	COSMIC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.3056
p.A286V	SIDM01577	Plasma Cell Myeloma	GDSC	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778
p.A286V	ACH-000889	Myeloma	CCLE	PTPQKT	DEG_SCF_FBW7_1	288:293	Mutation rewiring degron network	0.2778

Kaplan plot for DCX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCX

UniProt ID: O43602

Entrez ID: 1641

Protein name: Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCX in