DegronMD

Uniprot ID: O43602

Source protein: Neuronal migration protein doublecortin

Source gene: DCX

Class: DEG_SCF_FBW7_1

Location: 288:293

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 111.9167

COIL: 0.9362

CONS_SCORE: 0.743

DSS_SCORE: 0.8158

HELIX: 0.0312

FCONS_SCORE: 1.082

RIG_SCORE: 0.5618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L301V	TCGA-33-AASL	LUSC	TCGA	PTPQKT	DEG_SCF_FBW7_1	0.1111
p.L301V	DO219133	LUSC	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.1111
p.F288C	TCGA-AA-3984	COAD	TCGA	PTPQKT	DEG_SCF_FBW7_1	0.7108
p.F288C	DO9002	COAD	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.7108
p.E302K	TCGA-EE-A2GR	SKCM	TCGA	PTPQKT	DEG_SCF_FBW7_1	0.0833
p.E302K	DO37996	SKCM	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.0833
p.I295M	TCGA-TN-A7HL	HNSC	TCGA	PTPQKT	DEG_SCF_FBW7_1	0.2778
p.I295M	DO219080	HNSC	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.2778
p.K283T	DO50316	ESAD	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.1944
p.T303I	DO222420	MELA	ICGC	PTPQKT	DEG_SCF_FBW7_1	0.0556
p.K285N	SIDM00583	Pancreatic Carcinoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.3611
p.K285N	ACH-001107	Pancreatic Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	0.3611
p.K285N	KP-1N	pancreas	COSMIC	PTPQKT	DEG_SCF_FBW7_1	0.3611
p.P288S	SIDM00394	Cervical Carcinoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.6752
p.P288S	ACH-001650	Cervical Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	0.6752
p.P288S	SISO	cervix	COSMIC	PTPQKT	DEG_SCF_FBW7_1	0.6752
p.A286S	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.2778
p.A286S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.2778
p.S294L	SIDM01059	Melanoma	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.3056
p.S294L	ACH-000915	Skin Cancer	CCLE	PTPQKT	DEG_SCF_FBW7_1	0.3056
p.S294L	IPC-298	skin	COSMIC	PTPQKT	DEG_SCF_FBW7_1	0.3056
p.A286V	SIDM01577	Plasma Cell Myeloma	GDSC	PTPQKT	DEG_SCF_FBW7_1	0.2778
p.A286V	ACH-000889	Myeloma	CCLE	PTPQKT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43602	Neuronal migration protein doublecortin	DEG_SCF_FBW7_1	288:293	PTPQKT	FBXW7	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons