TRAF3IP2
UniProt ID: O43734
Entrez ID: 10758
Protein name: E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapt...
FUNCTION: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}.
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GO - Biological processes (BP):
B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0...
B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-17-mediated signaling pathway [GO:0097400]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; leukocyte activation involved in inflammatory response [GO:0002269]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; neutrophil activation [GO:0042119]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to P-body [GO:0110012]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092]
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GO - Molecular function (MF):
signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630]...
signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630]
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GO - Cellular component (CC):
cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]...
cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]
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TRAF3IP2
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Kaplan plot for TRAF3IP2 in
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*NOTE: the Kaplan plots were collected from OncoLnc